John Nicholas Selected Research

Kaposi Sarcoma (Kaposi's Sarcoma)

5/2024	Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7.
1/2021	Novel Functions and Virus-Host Interactions Implicated in Pathogenesis and Replication of Human Herpesvirus 8.
1/2020	Genetic Analyses of Contributions of Viral Interleukin-6 Interactions and Signaling to Human Herpesvirus 8 Productive Replication.
1/2019	Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication.
1/2018	Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase.
11/2017	Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding.
1/2014	Human herpesvirus 8 interleukin-6 contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin K epoxide reductase complex subunit 1 variant 2.
3/2010	Human herpesvirus 8-encoded cytokines.
2/2010	Induction of angiogenic chemokine CCL2 by human herpesvirus 8 chemokine receptor.
7/2008	Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.

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John Nicholas Research Topics

Disease

18	Primary Effusion Lymphoma 05/2024 - 09/2003
12	Kaposi Sarcoma (Kaposi's Sarcoma) 05/2024 - 09/2003
9	Neoplasms (Cancer) 01/2022 - 07/2005
9	Multi-centric Castleman's Disease 01/2021 - 09/2003
4	Virus Diseases (Viral Diseases) 05/2024 - 02/2010
4	Infections 11/2023 - 07/2008
1	Castleman Disease (Castleman's Disease) 05/2024
1	Bites and Stings (Sting) 11/2023
1	Lymphoma (Lymphomas) 01/2020

Drug/Important Bio-Agent (IBA)

9	Interleukin-6 (Interleukin 6)IBA 01/2020 - 01/2007
8	CytokinesIBA 01/2021 - 07/2005
6	Proteins (Proteins, Gene)FDA Link 11/2023 - 01/2007
5	viral interferon regulatory factorsIBA 11/2023 - 01/2007
4	Antiviral Agents (Antivirals)IBA 05/2024 - 09/2003
3	ChemokinesIBA 03/2010 - 01/2007
2	Viral ProteinsIBA 01/2020 - 01/2007
2	Cytokine Receptor gp130IBA 12/2017 - 10/2013
2	Cathepsin DIBA 08/2015 - 01/2014
2	Membrane Proteins (Integral Membrane Proteins)IBA 08/2015 - 01/2007
2	Vitamin K Epoxide ReductasesIBA 08/2015 - 01/2014
1	Interferon Regulatory FactorsIBA 05/2024
1	Phosphotransferases (Kinase)IBA 11/2023
1	Caspase 8 (Caspase-8)IBA 01/2022
1	TNF-Related Apoptosis-Inducing LigandIBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2020
1	Deubiquitinating EnzymesIBA 01/2020
1	ChromatinIBA 01/2020
1	TNF Receptor-Associated Factor 3IBA 01/2020
1	TNF Receptor-Associated Factor 6 (TRAF6)IBA 01/2020
1	Peptide Hormones (Polypeptide Hormones)IBA 01/2019
1	procathepsin DIBA 01/2019
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2010
1	CCAAT-Enhancer-Binding Protein-betaIBA 02/2010
1	CC ChemokinesIBA 07/2008
1	DNA (Deoxyribonucleic Acid)IBA 01/2007
1	Chemokine ReceptorsIBA 07/2005
1	LigandsIBA 09/2003

Therapy/Procedure

1	Therapeutics 01/2022